Clinical Trials for Patients

Adult Depression Study

While antidepressant medications are available to treat depression, some patients do not respond even after multiple treatments. This clinical research study will look at the effectiveness of an investigation medication (given as a nasal spray) in delaying the return of depression in patients who have not responded to prior treatment with at least two antidepressants.  

NPR All Things Considered just released an article about the study drug being used to treat depression. Please find the article here.  

depression sad hopeless


There are five phases in the study: 


  1. A screening phase (up to 7 weeks)
  2. An induction treatment phase (4 weeks)
  3. An optimization treatment phase (12 weeks)
  4. A maintenance treatment phase (length of time will be different for each patient)
  5. A follow-up phase (2 weeks)

Eligibility to be considered for this study, you must be:

  1. 18-64 years old
  2. Diagnosed with depression
  3. Experiencing depression symptoms despite having taken at least two medications in the past
  4. Comfortable with using a nasal spray
  5. Able to provide written consent to participate in the study

If you are eligible for this study and choose to participate, all study visits and study-related medical care will be provided at no cost to you. Compensation for your time and travel expenses may also be provided.